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The subjects treated with tirzepatide lost 21.4% of their body weight, on average, over 12 months, equating to 49.4lb (22.4kg)

Most people feel the strongest effects between weeks 4 and 8

Consciously tracking and maintaining activity levels prevents this adaptation

But it almost certainly reduces the gastrointestinal rebound effects that some researchers report after abrupt cessation, including paradoxical increases in appetite, changes in bowel habits, and blood sugar fluctuations